Contact: Tom Johnson, Director of Marketing Services
Telephone: (516) 333-8230 x3317 
Email: tjohnson@ezem.com 

E-Z-EM, Vital Images and R2 Technology Display Prototype 
Computer-Aided Detection Application for Virtual Colonoscopy

Companies Jointly Demonstrate Colon CAD Solution as a Work-in-Progress at RSNA 


Chicago, IL; December 5, 2002 - E-Z-EM, Inc. (AMEX: EZM) today announced that it is jointly 
demonstrating a prototype computer-aided detection (CAD) solution for CT colonography, also 
known as virtual colonoscopy, with Vital Images, Inc. (Nasdaq Smallcap: VTAL) and R2 Technology, 
Inc. The CAD solution, demonstrated by E-Z-EM on the Company’s innerviewGITM system, allows a 
radiologist to automatically segment and define regions of interest that may represent colon 
polyps in multislice CT (MSCT) exams. Although no formal agreement yet exists between E-Z-EM 
and R2 Technology for the development of a Colon CAD solution, the application was jointly 
demonstrated as a work-in-progress by the three companies at the 88th Annual Scientific Assembly 
of the Radiological Society of North America, held in Chicago, IL from December 1-6, 2002. 

Computer-aided detection is a software technology that is designed to identify suspicious areas 
during CT screening exams. The technology uses sophisticated computer algorithms to screen the 
thousands of images generated by the latest high-speed CT scanners for potential lesions, 
automatically marking suspect features for further evaluation by the radiologists. The 
technology addresses a growing need among radiologists whose ability to read and confidently 
assess CT imaging studies, such as virtual colonoscopy, is challenged by the volume of images 
to evaluate. It can take an experienced radiologist approximately 15 minutes to read a typical 
virtual colonoscopy study.

Commenting on the announcement, Anthony A. Lombardo, President and CEO of E-Z-EM, said "Though 
a CAD solution for virtual colonoscopy is in the earliest stages of development, we are 
delighted to be working with Vital Images and R2 Technology to demonstrate its potential 
through the prototype presented here at the RSNA. We believe that CAD capability will be an 
important component in virtual colonoscopy in the future, and though no formal agreement to do 
so currently exists, we plan to explore options for integrating the technology into 
innerviewGI."

Colon cancer is the second leading cause of cancer death in the United States. The American 
Cancer Society (ACS) estimates that about 150,000 new cases of colon cancer will be diagnosed 
in 2002. Colon cancer is expected to cause about 48,100 deaths and an estimated 8,500 men and 
women will die from rectal cancer during 2002.

About E-Z-EM

E-Z-EM, Inc. (www.ezem.com) is a leading supplier of products used by radiologists, 
gastroenterologists and speech language pathologists for the diagnostic imaging of diseases 
and disorders of the GI tract, ranging from swallowing disorders (dysphagia) to colorectal 
cancers. E-Z-EM is also a third-party contract manufacturer of diagnostic contrast media, 
pharmaceuticals, non-prescription healthcare products, and defense decontaminants.

About Vital Images

Vital Images is a leading provider of 3D imaging software for use in disease screening 
applications, clinical diagnosis and therapy planning. The Company’s technology utilizes 
high-speed volume visualization and analysis, as well as network communications based on DICOM 
and Internet protocols. Vital Images cost effectively brings 3D visualization and analysis into 
the day-to-day practice of medicine. Press releases, examples of 3D medical imaging and other 
corporate information are available on Vital Images’ newly updated Web site at 
www.vitalimages.com.

About R2 Technology, Inc.

R2 Technology, Inc., headquartered in Sunnyvale, CA, is a recognized leader in the development 
and commercialization of computer-aided detection (CAD), an innovative technology that assists 
radiologists in the early detection of breast cancer and other cancer-related lesions. R2's 
CAD software has been integrated with the ImageCheckerÒ processing and visual display system, 
and is being used successfully by hospitals and imaging centers as an aid to radiologists for 
increased detection of breast cancer. To date, more than 700 ImageChecker systems for use with 
film and digital-based mammography have been shipped worldwide. As a medical software company, 
R2 is developing CAD systems for a variety of imaging modalities and disease states, including 
lung cancer. For information, visit www.r2tech.com.

The statements made in this document contain certain forward-looking statements that involve a 
number of risks and uncertainties. Words such as "expects", "intends", "anticipates", "plans", 
"believes", "seeks", "estimates," or variations of such words and similar expressions, are 
intended to identify such forward-looking statements. Investors are cautioned that actual 
events or results may differ from the Company’s expectations. In addition to the matters 
described above, the ability of the Company to develop its products, future actions by the FDA 
or other regulatory agencies, results of pending or future clinical trials, overall economic 
conditions, general market conditions, market acceptance, foreign currency exchange rate 
fluctuations, the effects on pricing from Group Purchasing Organizations, competition, 
including alternative procedures which continue to replace traditional fluoroscopic procedures, 
as well as the risk factors listed from time to time in the SEC filings of E-Z-EM, Inc., 
including but not limited to its Form 10-Q for the quarter ended August 31, 2002, as well as 
its Annual Report on Form 10-K for the year ended June 1, 2002, may affect the actual results 
achieved by the Company.

innerviewGI is a trademark of E-Z-EM, Inc.

ImageChecker is a registered trademark of R2 Technology, Inc. 

End